Organoid technologies are transforming oncology drug development and disrupting the traditionally followed workflows. CrownBio holds an exclusive license from HUB to provide preclinical oncology drug development and validation services using world-leading HUB Organoid Technology, originally developed by the Clevers lab.
“Organoid models will revolutionize the way preclinical oncology research is performed,” said Henry Li, PhD, chief scientific officer at CrownBio. “Using organoids, drug screening will evolve from current linear workflows to a matrixed high throughput screening approach, allowing lead candidates to be tested simultaneously across multiple patient populations in an easily scalable and clinically-relevant model system.”
The newly available models join CrownBio’s established and ever-expanding platform of PDX-derived organoids (PDXO). PDXO are generated using HUB protocols to derive tumor organoids from CrownBio’s PDX collection, which is the world’s largest commercially available panel of PDX. The complementary panels of patient and PDX-derived organoids, alongside parental PDX models, provide the opportunity to change the way drug discovery is conducted.
The combined collection of in vitro and in vivo patient-derived models are clinically relevant and predictive, and the matched model pairs offer a more efficient and informed transition from in vitro to in vivo studies to help reduce the currently high attrition rates of anticancer agents.
“I am delighted to see the HUB Organoid biobank becoming available to the wider research community for oncology drug discovery,” said Rob Vries, PhD, chief executive officer of HUB. “Our partnership with CrownBio is continuing to equip pharmaceutical and biotech companies with the cutting-edge models needed to transform their anticancer agent development programs.”
Benefits of the newly available PDO models include the availability of non-malignant, healthy tissue-derived organoids. This enables PDO studies to be well controlled for studying compound toxicity and therapeutic windows, including matched tissue controls.
The new models cover the important indications of breast, colon, lung, and pancreatic cancer and are directly derived from European patients. The collection includes PDO from primary and metastatic lesions, multiple lesions from the same patient to capture intra-patient heterogeneity, as well as both healthy and tumor organoids.
CrownBio’s organoid platform is available to clients globally. The newly acquired PDO models have completed transfer to CrownBio. They are available for client studies immediately for efficacy and potency evaluation, combination strategy optimization, and lead candidate selection.
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